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Case study · AG1
Moving faster in formulation without compromising scientific rigor.
How FIOS and LEAP enabled the discovery of potential ingredient synergies, efficacy validation, and an order-of-magnitude reduction in evidence review time for a leading supplement brand.
4×faster concept to formulation
40ingredient synergies in < 2 hours
2→2evidence review from months to weeks
Building efficacious supplements at commercial speed.
AG1's product promise is comprehensive nutrition backed by scientific evidence. Every ingredient in the formula has to be justified against primary literature — safety, efficacy, dose-response, and synergy with every other ingredient in the stack.
Evidence review set the pace for the entire product development cycle. With every ingredient and dose decision requiring deep scientific support, the sheer volume of literature turned each review into a multi-month effort.
AG1 needed to move faster without moving to lower-evidence decisions.
The specific pain
Evidence review set the pace for the entire product development cycle. With every ingredient and dose decision requiring deep scientific support, the sheer volume of literature turned each review into a multi-month effort.
LEAP for evidence. FIOS for formulation. One workflow.
LEAP was used to surface ingredient-ingredient synergies across a corpus of 30+ million scientific articles — at a scale no manual review can match. The knowledge graph connects compounds to mechanisms to outcomes, turning 'which ingredients interact well?' from a research project into a query. FIOS helped handle the formulation work; dose optimization, stability prediction, compatibility checking, and production readiness. Every formulation decision was grounded in the evidence LEAP surfaced, with full traceability from claim to citation. The combined workflow cut evidence review from about eight weeks to roughly two weeks. Critically, scientific rigor was maintained throughout — every decision was still backed by primary literature.
What changed, in numbers.
4×Concept to formulationAG1's end-to-end timeline from concept kickoff to formulation-ready cut by roughly four-fold.
40Ingredient synergies per formulationEvidence-grounded potential synergies identified in under two hours at a scale impossible to achieve manually.
2 weeksEvidence review (down from 2 months)Manual literature review cycles that used to take a full quarter now fit inside a sprint.
30M+Articles analyzed per formulationThe full scope of FIOS's analysis draws on over 30 million scientific articles, structured for evidence traceability.