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Case study · AG1
Moving faster in formulation without compromising scientific rigor.
How LEAP™ accelerated evidence discovery and surfaced candidate ingredient synergies, while FIOS® supported faster formulation without compromising scientific rigor.
4×faster concept to formulation
40candidate synergies surfaced in under 2 hours
8→2weeks for evidence review
Building efficacious supplements at commercial speed.
AG1's product promise is comprehensive nutrition backed by scientific evidence. Every ingredient in the formula has to be justified against primary literature — safety, efficacy, dose-response, and synergy with every other ingredient in the stack.
Evidence review set the pace for the entire product development cycle. With every ingredient and dose decision requiring deep scientific support, the sheer volume of literature turned each review into a multi-month effort.
AG1 needed to move faster without moving to lower-evidence decisions.
The challenge
Each ingredient introduces questions around safety, efficacy, dose-response, and potential interactions. As formulations grew more complex, the volume of evidence to review increased, making literature review a bottleneck in the development process.
LEAP™ for evidence. FIOS® for formulation. One workflow.
LEAP™ surfaced candidate ingredient-ingredient synergies across more than 35 million scientific articles, connecting compounds to mechanisms and health outcomes through its knowledge graph. This gave the team a structured, traceable view of the published evidence around potential ingredient relationships.
FIOS® took that evidence into the formulation workflow, supporting dose optimization, stability prediction, compatibility checking, and production readiness. Together, LEAP™ and FIOS® reduced evidence review from about eight weeks to roughly two weeks, with the underlying science remaining traceable to primary literature throughout.
What changed, in numbers.
4×Concept to formulationAG1's end-to-end timeline from concept kickoff to formulation-ready cut by roughly four-fold.
40Candidate synergies surfacedEvidence-grounded potential synergies identified in under two hours at a scale impossible to achieve manually.
2 weeksEvidence review — down from ~8 weeksEvidence review cycles that previously took about eight weeks were reduced to roughly two weeks.
35M+Scientific articlesLEAP™ searched and connected the published evidence behind candidate ingredient relationships, with results traceable to source literature.